Endocrine Abstracts

Objectives: To evaluate the prevalence of subclinical hypertension detected by ambulatory blood pressure monitoring (ABPM) and its relationship with some clinical and epidemiological factors in normotensive and normoalbuminuric patients with type 1 diabetes.Patients and methods: Transversal study that included patients with type 1 diabetes, older than 18 years, with clinic blood pressure lower than 130/80 mmHg and absence of microalbuminuria. Twenty-four...

Objectives: To determine the lifestyle in patients with morbid obesity in a previous group and in a group after performing bariatric surgery.Material and methods: Cross-sectional study in two groups of patients with morbid obesity one before and one after bariatric surgery attended in the Clinical Management Unit of Endocrinology and Nutrition of the Puerta del Mar Hospital in Cádiz. The clinical and analytical data of the patients, the sociodemogra...

The relationship between gestational diabetes mellitus (GDM) and oxidative stress is not well known and the effect of oxidative stress in GDM placenta and the impact that could have on perinatal morbidity and risk of future complications is also yet to be elucidated. The aim of the study was to evaluate the relationships between maternal and placental tissue levels of markers of oxidative stress and antioxidants in women with GDM, which potentially may have considerable clinic...

Objectives: 1. To evaluate the effect after two years of bariatric surgery on comorbidities in patients with diabetes mellitus type 2 (DMT2) and obesity grade II or higher.2. Analyze the surgical complications in these patients.Material and methods: Cohort study with intrasubject measures (before-after) in patients with grade II or higher obesity and T2DM, who underwent bariatric surgery (gastric bypass or vertical gastrectomy) at ...

The effect of subclinical hypothyroidism (SH) and thyroid autoimmunity on adverse pregnancy and neonatal outcome, are still subject of interest and controversy. Nowadays, guidelines recommend establishing reference values of local thyroid hormones that allow definition of the SH in a specific population. The objective of this study was to assess the effect of SH and autoimmunity in early pregnancy on adverse pregnancy and neonatal outcome in our population. The reference range...

Background and aims: The mechanisms underlying placenta oxidative stress co-existing with alterations in maternal-placenta interactions during gestational diabetes mellitus (GDM) are not well understood. We sought to evaluate the levels of oxidative stress markers and antioxidants in women with GDM, and to assess the impact on placenta.Material and methods: Pregnant women (63 with GDM, 63 controls) were enrolled, together with 41 cases and 21 controls fo...

Introduction: New treatments of diabetes, such as dapagliflozin, improve global metabolic status beyond glycemic control.Aim: To evaluate tolerance to dapagliflozin and its effects on metabolic control in type 2 diabetes and obese patients attended in endocrinology offices.Material and method: A prospective study of patients with type 2 diabetes and obesity. In an intra-subject analysis, clinical and analytical data were evaluated ...

Introduction: The prevalence of obesity has increased, reaching epidemic proportions. Framingham and REGICOR scales predict the likelihood of developing a coronary event in the next 10 years. The aim of this study was to assess the concordance of these scales in the stratification of cardiovascular risk (CVR) in a cohort of patients with morbid obesity.Methods: We designed a cross-sectional study in a sample of patients with morbid obesity evaluated from...

Introduction: In preliminary results of our group, we detected an association between the mean nocturnal blood pressure and development microvascular complications. The objective was to evaluate possible nocturnal blood pressure cut off points in relation to the development or progression of retinopathy, microalbuminuria and arterial hypertension in type 1 diabetic patients.Methods: We designed a prospective observational study of 85 patients, clinically...

Background and aims: The relationship between gestational diabetes mellitus (GDM) and oxidative stress is not well known and the effect of both oxidative and nitrosative stress in GDM placenta and the impact that could have on perinatal morbidity and risk of future complications is still pending to be elucidated. The aim of the study was to evaluate the relationships between maternal and placental tissue levels of markers of nitrosative and oxidative stress and antioxidants in...